InvestorWire NewsRoom


CNS Pharmaceuticals (NASDAQ: CNSP) Advances Brain Cancer Drug Candidate and Sponsors Annual SNO Conference
December 1, 2020

CNS Pharmaceuticals (NASDAQ: CNSP) Advances Brain Cancer Drug Candidate and Sponsors Annual SNO Conference

  • Biotechnology developer CNS Pharmaceuticals is preparing, with its partner WPD Pharmaceuticals, a global set of Phase 2 trials for its drug candidate Berubicin, which has shown promise in combating the effectively fatal glioblastoma multiforme (“GBM”) brain cancer
  • Since another company conducted Phase 1 safety trials for Berubicin 14 years ago, one patient has survived cancer-free while two others saw reductions in tumor size of up to 80 percent
  • The Phase 2 trials will build on the Phase 1 results, conducting targeted testing that offers side-by-side comparison between Berubicin and chemotherapy drug lomustine in real time beginning next year
  • The company is also preparing with WPD to conduct the first Phase I trials of Berubicin in children in Europe
  • CNS Pharmaceuticals officers recently participated virtually in the annual Society for Neuro-Oncology (“SNO”) Scientific Meeting and Education Day to promote their work and discuss the progress of clinical trials

While the world’s attention remains occupied with developments related to the global coronavirus pandemic that has infected about 60 million people and claimed the life of nearly 1.5 million of them (, a dedicated group of researchers continues to pursue breakthroughs on the nearly always fatal glioblastoma multiforme (“GBM”) type of brain cancer. Recently, the Society for Neuro-Oncology (“SNO”) held its 25th Annual Scientific Meeting and Education Day to spotlight the efforts of over 2,600 researchers and clinician scientists from more than 40 countries in researching and treating GBM and similar brain cancers (

CNS Pharmaceuticals (NASDAQ: CNSP) appeared at the virtual conference through a joint sponsorship with WPD Pharmaceuticals, staffing a booth in the virtual exhibit hall while Dr. Patrick Wen, a member of CNS’s Science Advisory Board, participated in a panel discussion on clinical trials during the plenary session Nov. 20, and in online poster presentations throughout the three-day event (

CNS Pharmaceuticals is preparing to launch a Phase 2 trial of its leading drug candidate, Berubicin, an anthracycline that has demonstrated significant potential in appearing to effectively cross the blood-brain barrier and effectively targeting central nervous system malignancies.

The medical science companies presenting their progress toward a more effective treatment of glioblastomas at the SNO conference generally focused on the safety and tolerability of using their drug candidates in animals or early-stage human trials. CNS appears to have an advantage in that Berubicin not only demonstrated safety in the Phase 1 trials conducted by another company 14 years ago; the clinical benefit response of stable disease or better was 44 percent with one patient who still remains alive and cancer-free and another two patients whose tumors shrunk by up to 80 percent.

CNS has obtained Orphan Drug Designation (“ODD”) for Berubicin in treating malignant gliomas and announced Nov. 17 that it has now filed an Investigational New Drug (“IND”) application with the U.S. Food and Drug Administration (“FDA”) which has been accepted for review (

The company’s Phase 2 trial will recruit 243 patients for side-by-side, real-time analysis of Berubicin’s performance against the chemotherapy standard of care drug lomustine. The trials will take place on a global scale, administering Berubicin to 162 tumor patients and Iomustine to the other 81 in about 60 study centers scattered across North America, Europe and the Asia-Pacific region, company officers said in a November webinar (

“We are evaluating responses defined as a decrease in the size of the tumor, as well as stability of the disease defined as no further increases in the size of the tumor once the patient is put on study, as well as the time to progression of these tumors and importantly overall survival of the patients,” CMO Dr. Sandra Silberman said during the webinar.

Existing treatments mostly avail themselves of surgery and the drug temozolomide, which has been shown effective in temporarily extending the lifespan of fewer than 40 percent of GBM patients with a specific genetic variation. But overall, glioblastoma patients have a median survival rate of only 14.6 months from the date of the malignancy’s diagnosis as the cancer recurs and resists new interventions — a significant reason why the Berubicin trial participant’s survival for 14 years without cancer is so exciting.

CNS expects the trial enrollment to take two to two and a half years with funding occurring in stages as critical benchmarks are achieved. CEO John Climaco said the trial could potentially lead Berubicin toward an expedited regulatory pathway, which would save time and money in the long run.

CNS is also simultaneously pursuing a first-ever Phase I Berubicin safety trial in Poland for children who have the GBM tumor and have run out of other medical options. This trial is being conducted by WPD Pharmaceuticals, a CNS sub-licensee.

For more information, visit the company’s website at

NOTE TO INVESTORS: The latest news and updates relating to CNSP are available in the company’s newsroom at

About InvestorWire

InvestorWire is the wire service that gives you more. From regional releases to global announcements presented in multiple languages, we offer the wire-grade dissemination products you’ll need to ensure that your next press release grabs the attention of your target audience and doesn’t let go. While our competitors look to nickel and dime you with hidden fees and restrictive word limits, InvestorWire keeps things transparent. We offer UNLIMITED Words on all domestic releases. While other wire services may provide a basic review of your release, InvestorWire helps you put your best foot forward with complimentary Press Release Enhancement.

With our competitors, the work is done the second your release crosses the wire. Not with InvestorWire. We include follow-up coverage of every release by leveraging the ever-expanding audiences of the 50+ brands that make up the InvestorBrandNetwork.

Get more out of your next press release with InvestorWire. It’s unlike anything you’ve seen before.

For more information, please visit

Please see full terms of use and disclaimers on the InvestorBrandNetwork website applicable to all content provided by IBN, wherever published or re-published:

InvestorWire (IW)
8033 Sunset Blvd Suite 1037-IW
Los Angeles, CA 90046
310.299.1717 Office
[email protected]

InvestorWire is part of the InvestorBrandNetwork.

Get Started with InvestorWire

To distribute a release in the next 24 hours. Contact our client services team.

(862) 930-1404

Distribute a press release. Submit your release to get started.

Submit Press Release

Set up a Live demonstration. Schedule a date and time that works for you.

Schedule a LIVE Demo

Press Distribution

Explore Press Distribution Solutions

All releases include an unlimited word count* with full wire-grade syndication, our press release enhancement service, and a follow-up InvestorNewsBreak article distributed to thousands of editorial syndication partners.

Discover Add-on Solutions

Increase the impact of your achievements by adding these exclusive solutions from InvestorWire, delivered in conjunction with the InvestorBrandNetwork (IBN).