• LIXTE has acquired Liora Technologies Europe Ltd., securing its proprietary LiGHT system for advanced proton therapy treatment
• Liora works at the forefront of electronically controlled proton beam innovation, with its platform installed at the UK’s STFC Daresbury Laboratory
• These updates highlight LIXTE’s overarching mission to blend breakthrough drug development with transformative radiotherapy innovations in the global cancer fight

Cancer is still one of the most widespread life-threatening diseases globally, with nearly all families affected either directly or as caregivers. Innovations in the medical ecosystem continue to gain momentum with the emergence of new immunotherapies, targeted drugs, and advanced radiation treatments. In light of this, LIXTE Biotech (NASDAQ: LIXT) is complementing traditional drug development into the rapidly evolving field of proton therapy, utilizing Liora Technologies, its newly acquired subsidiary (ibn.fm/UihRx).

Towards the end of 2025, the company finalized its acquisition of Liora, signaling its foray into the radiotherapy segment of cancer care. This strategic move includes Liora’s LiGHT system, which stands for Linac for Image Guided Hadron Therapy. This platform is designed to enhance the delivery of proton therapy and address identified limitations in many conventional systems (ibn.fm/mPijd).

Proton therapy is an improved form of radiation therapy that leverages proton particles instead of regular X-rays to destroy tumor DNA. Protons, unlike photon radiation, release most of their energy at a precise depth within the body. This feature helps doctors better target tumors while cutting down radiation exposure to nearby healthy tissue. The precision is crucial when tumors are found close to organs such as the spinal cord, brain, lungs, or heart, and it can be useful for children who are likely to be more susceptible to long-term side effects resulting from radiation (ibn.fm/QqpkB).

Although proton therapy has its own unique clinical benefits, traditional systems are usually complex, large, and expensive. Many such therapies depend on synchrotrons or cyclotrons that require significant resources. These barriers have limited the number of proton therapy centers globally.

Liora’s LiGHT system is currently installed at the Science and Technology Facilities Council Daresbury Laboratory in Britain, with over $300 million invested in it so far. The electronically controlled system enables adaptability, flexibility, and the potential for lower costs of installation compared to the regular alternatives.

The LiGHT system is also created to deliver high dose rates to deep-seated tumors, reducing the number of treatment sessions needed while increasing the total number of patients a treatment center can handle. Improved efficiency could also help improve proton therapy access while also optimizing the financial model for operators.

LIXTE’s acquisition of Liora highlights a strategic expansion that goes beyond its regular pharmaceutical pipeline, with the company’s lead drug candidate, LB 100, currently being assessed in clinical trials for ovarian clear cell carcinoma and metastatic colon cancer. By blending advanced radiation technology and innovative drug development, the company is creating a solid oncology platform that tackles cancer from a broader angle.

Given the growing demand for more effective cancer treatment options, LIXTE’s entry into proton therapy through Liora Technologies and the LiGHT system holds significant potential. Through the blend of next-generation radiation therapy and pharmaceutical innovation, the company is working hard to improve cancer treatment while also creating opportunities for investors.

For more information, visit the company website at https://lixte.com.

NOTE TO INVESTORS: The latest news and updates relating to LIXT are available in the company’s newsroom at ibn.fm/LIXT

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