AUM Biosciences is a global clinical-stage oncology company focused on advancing a pipeline of precision oncology therapeutics designed to deploy multi-faceted inhibition strategies to reverse cancer resistance. AUM is advancing a broad portfolio of precision oncology therapeutics. AUM001 is a selective and synergistic MNK inhibitor as shown in current studies and expected to be evaluated in a Phase 2 clinical trial in metastatic colorectal cancer with enrollment on track to commence in the first half of 2023. AUM601 is a promising Phase 2 ready therapy for Tropomyosin Receptor Kinase (“TRK”) fusions and mutations within the kinase domain and has received Orphan Drug Designation for the treatment of solid tumors with the NTRK fusion gene from the US FDA. AUM302 is a potentially first-in-class macrocyclic oral kinase inhibitor rationally designed small molecule to uniquely combine pan-PIM kinase, pan-PI3K and mTOR inhibition in a single agent, and has received Orphan Drug Designation for the FDA for the treatment of neuroblastoma, as well as Pediatric Review Designation. Comprised of pharma industry veterans with decades of research and development experience, the AUM leadership has an extensive track record of selecting distinctive early-stage assets, successfully exiting virtual biotech models, and has contributed to over 50 INDs and over 150 oncology clinical trials, and development of several currently marketed oncology treatments with annual peak sales up to $3 billion. For more information, visit the company’s website at https://aumbiosciences.com/.
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