• LIXTE recently expanded its ovarian clear cell cancer trial in partnership with MD Anderson and GSK
• The company operates at the nexus of targeted cancer biology and combination therapy innovation
• These partnerships help underscore LIXTE’s broader strategy: enhancing established cancer treatments through its first-in-class compound LB 100

LIXTE Biotechnology Holdings (NASDAQ: LIXT) continues to promote its lead oncology asset, LB 100, through a partnership-driven model designed to accelerate development and improve scientific validation. Recently, the company announced the expansion of its ongoing clinical collaboration with the University of Texas MD Anderson Cancer Center and GSK plc to evaluate LB 100 in combination with dostarlimab for the treatment of ovarian clear cell carcinoma (https://nnw.fm/xi8sP).

The trial, initiated in January 2024, has met its initial enrolment target of 21 patients and is expected to grow to 42 participants. Results from the first cohort are projected to be out within the first half of 2026. The company’s decision to increase enrollment indicates institutional confidence in both operational execution and the underlying scientific rationale backing LB 100’s combination potential.

Experienced clinical investigators at MD Anderson spearhead the research and have since expanded to include a second site at the Robert H. Lurie Comprehensive Cancer Center, further improving recruitment capabilities and academic engagement. Multi-site collaboration improves the credibility of trial data and expands exposure within the oncology research community, both of which are often critical to future regulatory and partnership discussions.

Instead of developing LB 100 as a standalone therapy, the company focuses on improving the overall effectiveness of known treatments such as chemotherapy and immune checkpoint inhibitors. By combining LB 100 with approved immunotherapies such as dostarlimab, the company aims to address persistent resistance mechanisms that affect outcomes in difficult-to-treat cancers.

Beyond its collaboration with GSK and MD Anderson, the company has also partnered with Roche Holding AG in evaluating LB 100 in additional immunotherapy combinations. LIXTE’s partnership with globally reputed pharmaceutical leaders buttresses the scientific relevance of LB 100 and expands optionality for future development pathways.

The company’s partnership-focused strategy comes with a couple of advantages. It leverages the infrastructure and clinical expertise of premier institutions, creates defined data catalysts, and shares development risk. The expected 2026 data presentation highlights a potential inflection point that could influence strategic positioning and valuation.

The updates underscore the company’s broader mission: to boost cancer treatment outcomes by improving the therapies currently at the core of modern oncology. Through its strategic collaborations with leading academic centers and pharmaceutical innovators, the company is positioning LB 100 within credible clinical frameworks designed to accelerate and unlock long-term shareholder value.

For more information, visit the company website at https://lixte.com.

NOTE TO INVESTORS: The latest news and updates relating to LIXT are available in the company’s newsroom at https://ibn.fm/LIXT

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