TransCode Therapeutics (NASDAQ: RNAZ) and Quantum Leap Healthcare Collaborative announced a collaboration to evaluate TransCode’s lead therapeutic candidate TTX-MC138 in the PRE-I-SPY Phase 2a clinical trial platform, which plans to enroll up to 45 colorectal cancer patients who are ctDNA positive following standard curative-intent therapy. Beginning in the first half of 2026 and led by Dr. Paula Pohlmann of MD Anderson Cancer Center, the study will assess the biological and clinical activity of TTX-MC138 in the minimal residual disease setting, where recurrence risk is high and therapeutic options are limited, reflecting growing interest in precision treatments targeting micrometastatic disease.
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About TransCode Therapeutics
TransCode Therapeutics is a clinical stage company pioneering immunoncology and RNA therapeutic treatments of high risk and advanced cancers. The company’s lead therapeutic candidate, TTX-MC138, is focused on treating metastatic tumors that overexpress microRNA-10b, a unique, well-documented biomarker of metastasis. In addition, TransCode has a portfolio of other first-in-class therapeutic candidates designed to mobilize the immune system to recognize and destroy cancer cells.
NOTE TO INVESTORS: The latest news and updates relating to RNAZ are available in the company’s newsroom at https://ibn.fm/RNAZ
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