Soligenix (SNGX) is spotlighting new interim data on HyBryte(TM) (synthetic hypericin) for early-stage cutaneous T-cell lymphoma (CTCL) in a recent podcast hosted by the Cutaneous Lymphoma Foundation. Featured guest Dr. Ellen Kim, Principal Investigator of the ongoing investigator-initiated study and Director of the Penn Cutaneous Lymphoma Program, reported a 75% treatment success rate at 18 weeks and up to 85% improvement in patients treated through 54 weeks. The study builds on prior results from the Phase 3 FLASH trial and mirrors the design of the current FLASH2 confirmatory trial, now enrolling patients. Dr. Kim emphasized HyBryte’s safety and tolerability, with no serious side effects reported and only one patient dropout due to logistical reasons.
Designed to reflect real-world clinical practice, the open-label study eliminates rest periods and extends treatment duration—approaches that appear to boost efficacy. In the podcast, Dr. Kim underscored the limitations of existing skin-directed therapies and the urgent need for new options, particularly for early-stage CTCL. With its non-mutagenic mechanism and rapid response time, HyBryte is emerging as a potentially safer, faster-acting alternative to traditional treatments like steroids, chemotherapy, and phototherapy, offering renewed hope for patients with this chronic and underserved cancer.
To view the podcast, visit https://ibn.fm/sCfYo
About Soligenix Inc.
Soligenix is a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need. Its Specialized BioTherapeutics business segment is developing and moving toward potential commercialization of HyBryte(TM) (“SGX301” or synthetic hypericin) as a novel photodynamic therapy utilizing safe visible light for the treatment of cutaneous T-cell lymphoma (“CTCL”). With successful completion of the second Phase 3 study, regulatory approvals will be sought to support potential commercialization worldwide. Development programs in this business segment also include expansion of synthetic hypericin (“SGX302”) into psoriasis, the company’s first-in-class innate defense regulator (“IDR”) technology, dusquetide (“SGX942”) for the treatment of inflammatory diseases, including oral mucositis in head and neck cancer, and (“SGX945”) in Behçet’s disease.
The company’s Public Health Solutions business segment includes development programs for RiVax(R), its ricin toxin vaccine candidate, as well as its vaccine programs targeting filoviruses (such as Marburg and Ebola) and CiVax(TM), the company’s vaccine candidate for the prevention of COVID-19 (caused by SARS-CoV-2). The development of Soligenix’s vaccine programs incorporates the use of its proprietary heat stabilization platform technology, known as ThermoVax(R). To date, this business segment has been supported with government grants and contract funding from the National Institute of Allergy and Infectious Diseases (“NIAID”), the Defense Threat Reduction Agency (“DTRA”) and the Biomedical Advanced Research and Development Authority (“BARDA”).
For further information, visit the company’s website at www.Soligenix.com .
NOTE TO INVESTORS: The latest news and updates relating to SNGX are available in the company’s newsroom at https://ibn.fm/SNGX
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